Mixed Phenotype Acute Leukemia (MPAL) comprises either blasts with myeloid and lymphoid expression or leukemia with a mixture of myeloblasts and lymphoblasts.
- BIPHENOTYPIC – single population of blasts that express key markers of different lineages (e.g. T-ALL, B-ALL, and/or AML).
- BILINEAL – two cell populations each diagnostic of separate acute leukemia lineages (combined populations ≥20% blasts to met threshold for acute leukemia).