CD25 is an IL-2 receptor.  CD25 is most often used as a marker for hairy cell leukemia, systemic mastocytosis, and adult T cell leukemia/lymphoma.  CD25 may stain activated B and T cells and cases of lymphoplasmacytic lymphoma (LPL).  CD25 is similar to CD30 in that it is an “activation” marker, and not specific.  Macrophages, and osteoblasts also often express CD25.

 

Non-neoplastic mast cells, marginal zone B cell lymphoma, T cell large granular leukemia/lymphoma, and variant hairy cell leukemia are usually negative for CD25.

Bone Marrow IHC.  Torlakovic, EE, et. al. American Society for Clinical Pathology Pathology Press © 2009.  pp. 75-76.

 

Diagnostic Immunohistochemistry:  Theranostic and Genomic Applications [edited by] David J. Dabbs. 3rd Edition.  pp. 165.

 

Lin, P., Molina, T. J., Cook, J. R., & Swerdlow, S. H. (2011). Lymphoplasmacytic lymphoma and other non-marginal zone lymphomas with plasmacytic differentiation. American Journal of Clinical Pathology, 136(2), 195–210. doi:10.1309/AJCP8FOIVTB6LBER

 

Karube, K., Suzumiya, J., Okamoto, M., Takeshita, M., Maeda, K., Sakaguchi, M., et al. (2007). Adult T-cell lymphoma/leukemia with angioimmunoblastic T-cell lymphomalike features: Report of 11 cases. The American Journal of Surgical Pathology, 31(2), 216–223. doi:10.1097/01.pas.0000213325.79368.2c

 

Siegert, S. I., Diebold, J., Ludolph-Hauser, D., & Löhrs, U. (2004). Are gastrointestinal mucosal mast cells increased in patients with systemic mastocytosis? American Journal of Clinical Pathology, 122(4), 560–565. doi:10.1309/2880-LF7Q-6XK3-HA3Q

 

Lin, P., & Medeiros, L. J. (2005). Lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia: an evolving concept. Advances in Anatomic Advances in Anatomic Pathology, 12(5), 246–255.