Smoldering (Asymptomatic) Myeloma
- >3 gm/dL serum M protein (or) urinary M protein ≥500 mg/24 hours
- (and/or) 10-60% bone marrow plasma cells (usually 10-20% plasma cells)
- Asymptomatic patients with no evidence of end-organ damage or biomarker evidence of malignancy (myeloma-defining events)