General
- Many cases of myelodysplasia (MDS-RS) and MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) are associated with SF3B1 mutations.
- SF3B1 – splicosome gene, often comuted with JAK2 in cases of MDS/MPN-RS-T (less frequently CALR and MPL)
- Only 5% RS is required to diagnosis MDS-RS if a SF3B1 mutation is identified. If no mutation, then the 15% RS threshold remains.
Photomicrographs
![Ringed Sideroblasts in MDS](https://www.pathmd.com/wordpress/wp-content/uploads/2017/10/MDS_RS-6-1024x768.jpeg)
![Ringed Sideroblasts in MDS](https://www.pathmd.com/wordpress/wp-content/uploads/2017/10/MDS_RS-8-1024x768.jpeg)