CD20 is a pan B-cell marker and is one of the most utilized hematopathology stains. The staining pattern morphology is membraneous and cytoplasmic. The sensitivity and specificity for mature B-cell neoplasms is very high.
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CD19
CD19 is a B-cell marker. Until recently this antibody has only been available for use in flow cytometry. Now CD19 is available as an immunohistochemistry (IHC) marker, with similar sensitivity for B-cells to CD20. The IHC expression pattern is cytoplasmic and membranous. It is normally expressed on both Precursor B-cells and B-cells. CD19 combined with TdT would be specific to detect precursor B-cells. CD20 is not expressed on precursor B-cells, but mature B-cell with surface light chain expression (usually).