Tag Archives: sclerosing adenosis

Breast – Sclerosing Adenosis

Sclerosing Adenosis (SA) is an increased density of duct-lobular acini, which characteristically are compressed in the central portion of the lesion with dense stroma/fibrosis.  Sometimes these lesions can closely mimic an invasive ducatal carcinoma, immunohistochemistry is necessary to separate lesions.
 
SA is not a neoplastic process, but is associated with a 1.5-2X increased relative risk for breast carcinoma.
Breast lesions and risk of developing an invasive carcinoma
Breast Cancer Risk Chart
Breast Cancer Risk Chart

References
Kumar, Vinay, Abul K. Abbas, and Jon C. Aster. Robbins and Cotran Pathologic Basis of Disease. Ninth edition. Philadelphia, PA: Elsevier/Saunders, 2015.